Use of Exfoliative Cytology in the Detection of Bladder Cancer

摘要

Groups of 96 female mice were given 2-Acetylaminofluorene (2-AAF) in their diet at either 100 ppm or 500 ppm until they were removed from the experiment or terminally sacrificed. Control groups of 986 mice/group were also used. Two types of exfoliative cells were monitored: 'suspicious' cells (cytology) and red blood cells (microhematuria). The mice were checked monthly for the appearance of the above mentioned cells in the urine. For each of the cell types, two methods were used for removal of mice from the experiment: (1) the first appearance of the cells, or (2) the detection of the cells for two out of three consecutive weeks. The conclusion derived from this study was that neither method could be used to predict bladder cancer at an early stage.