Neoplastic Effect of Vinyl Chloride in Mouse Lung - Lower Doses and Short-Term Exposure

摘要

The neoplastic pulmonary effects of vinyl-chloride (75014) (VC) were studied in mice. Male CD1-mice were exposed to VC vapor at concentrations of 2500 or 6000 parts per million (ppm) for 5 to 6 months. Ninety six percent of the mice exposed to 2500 or 600ppm VC developed pulmonary tumors. The author concludes that alveologenic tumors arose as a result of a transformation of type II epithelium through a hyperplastic form.