Preclinical Intravenous Toxicity Study of Homoharringtonine (NSC 141633) in CDF1 Mice and Beagle Dogs: Phase II, Task I

摘要

In CDF1 mice administered a single intravenous dose of homoharringtonine, calculated estimates of the LD(10), LD(50), and LD(90) were 4.26, 5.99, and 8.42 mg/kg (12.78, 17.97, and 25.26 mg/sq m, respectively). Estimates for mice administered five consecutive daily doses were 1.94, 2.88, and 4.27 mg/kg/day (5.82, 8.64, and 12.81 mg/sq m/day). There was no apparent sex difference.