Development, Implementation, and Evaluation of the Monitoring and Evaluation of Drug Interactions by a Pharmacy Oriented Reporting System (Mediphor)

摘要

This report describes the development, implementation, and evaluation of the MEDIPHOR computer-based system. The MEDIPHOR (Monitoring and Evaluation of Drug Interactions by a Pharmacy Oriented Reporting) system is used by pharmacists for alerting physicians about potential drug reactions. The report provides a detailed description of this system (including a computer user's manual) and the current system configuration at the Stanford University Medical Center. Descriptions of the earlier system protypes and preliminary evaluation studies are included. Finally, the evaluation of MEDIPHOR at two community hospitals in Indiana is presented. This section includes the design used for the study, data sources, questionnaires, results, and a discussion of operational problems in interpreting the results and evaluating a system like MEDIPHOR. The results of the evaluation studies indicate that overall approximately one of every six patients was prescribed one or more potentially interacting drug combinations prior to using MEDIPHOR. The initial evaluation of MEDIPHOR at Stanford University Hospital showed statistically significant effects on both the actions of physicians and the consequences of these actions, whereas the study at the two community hospitals in Indiana showed effects on actions only.