Eye Irritation Testing: An Assessment of Methods and Guidelines for Testing Materials for Eye Irritancy

摘要

The ocular safety of materials is determined primarily by observing the irritation produced by test agents instilled directly into the rabbit eye. The object of this study was to review the scientific basis for published guidelines, particularly those recently developed by the Organization for Economic Cooperation and Development (OECD) and the Interagency Regulatory Liaison Group (IRLG). These guidelines are essentially the same and recommend instillation of 0.1 ml material into the rabbit eye with observation for at least 72 hr.