Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report, Hexachloro-1,3-Butadiene

摘要

The Tier II mutagenic screening of hexachloro-1,3-butadiene (87683) (HCBD) was conducted. The unscheduled DNA synthesis (UDS) assay was conducted with human embryonic intestinal cells, rat liver S9, and 0.15 to 1000 micrograms per milliliter HCBD. A cytogenetic analysis of rat bone marrow cells was performed after in vivo exposure to 10 or 50 parts per million (ppm) HCBD for 7 hours per day for 1 or 5 days. The author concludes that HCBD was not mutagenic under these test conditions.