Correlation of Effects of Inhaled Versus Intratracheally Injected Metals on Susceptibility to Respiratory Infection in Mice

摘要

Effects of intratracheally administered air pollutant chemicals on susceptibility of mice to infection by aerosolized bacteria were compared with effects of the same chemicals previously studied by the inhalation route. Out of 22 compounds previously studied by inhalation, the same 3 that caused significantly increased mortality because of infection after a 3-h exposure to 1 to 2 mg/cu. m. showed large mortality increases when administered by intratracheal injection at lung concentrations calculated to be equivalent to those achieved during inhalation exposures.