Effect of 'In vivo' Ozone Exposure to Dorset Sheep, an Animal Model with Low Levels of Erythrocyte Glucose-6-Phosphate Dehydrogenase Activity

摘要

Considerable interest has recently been directed to the possible extrapulmonary effects caused by exposure to ambient ozone. Studies have now demonstrated that ozone exposure may result in chromosomal aberrations in circulating lymphocytes of Chinese hamsters, altered drug metabolism in mice, as well as biochemical changes in red blood cell metabolism in several animal models and humans. As a result of ozone induced in vivo alteration of red cell function within human subjects, Calabrese et al. (1977) hypothesized that individuals with an erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency would be at increased hemolytic risk to elevated ambient ozone exposure.