NTP Technical Report on the Toxicology and Carcinogenesis Studies of N,N-Dimethyl-p-Toluidine (Cas No. 99-97-8) in F344/N Rats and B6C3F1/N Mice (Gavage Studies).

摘要

N,N-Dimethyl-p-toluidine was nominated for toxicology and carcinogenesis studies by the National Cancer Institute based on the potential for human exposure through its use in dental materials and bone cements and the lack of toxicity and carcinogenicity data. Male and female F344/N rats and B6C3F1/N mice were administered N,N-dimethyl-p-toluidine (greater than 99% pure) in corn oil by gavage for 3 months or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium and Escherichia coli, mouse peripheral blood, and mouse and rat liver.