Subchronic Toxicity of Chlorine Dioxide and Related Compounds in Drinking Water in the Nonhuman Primate

摘要

Subchronic toxicities of Cl02, NaCl03, and NH2Cl were studied in the African Green monkeys (Cercopithecus aethiops). The chemicals were administered in drinking water during 30-60 days subchronic rising dose protocols. The only unexpected and significant toxic effects was elicited by Cl02; this chemical inhibited thyroid metabolism in the animals at a dose of ca.9.0 mg/kg/day.