Information Profiles on Potential Occupational Hazards: Thiourea and Compounds

摘要

Information profiles are presented for thiourea and the following thiourea compounds: 1-allyl-3-(2-hydroxyethyl)-2-thiourea (105817), allylthiourea (109579), N,N'-bis(hydroxymethyl)thiourea (3084251), N,N'-bis(methoxymethyl)thiourea (51872265), 1-butyl-3-ethyl-2-thiourea (32900064), 1,3-dibutyl-2-thiourea (109466), 1,3-diisopropyl-2-thiourea (2986176), 1,3-dimethyl-2-thiourea (534134), N'N'-di-o-tolylthiourea (137973), 3-ethyl-1-1,1-dimethyl-2-thiourea (15361861), ethylthiourea (625536), (hydroxymethyl)thiourea (1000835), (2-methylphenyl)thiourea (614788), thiourea (62566), 1,3-diethyl-2-thiourea (105555), 1,3-diphenyl-2-thiourea (102089), ethylenethiourea (96457), 1-naphthylthiourea (86884), 1-phenyl-2-thiourea (103855), 1,1,3,3-tetramethylthiourea (2782914) and 1,1,3-trimethyl-2-thiourea (2489772). Most of the compounds were highly toxic to rodents. Positive mutagenic effects have been elicited in various assays with several of these compounds. The use of thiourea, diethylthiourea and tetramethylthiourea as antithyroid drugs indicated these compounds have antithyroidal effects in humans. Frequently observed side effects from the use of these medications include headache, anxiety, fever, skin rash, and gastrointestinal disturbances.