Operation of the Molecular Virology and Immunology Laboratory (Georgetown University, Rockville, Maryland). Annual Report October 11, 1981-October 3, 1982

摘要

Contents: Woodchuck hepatitis virus (WHV) (Serological assays and antigenic analysis of WHV antigens); Experimental transmission of WHV to susceptible woodchucks and preliminary vaccine studies; Characterization and development of HBV vaccines (HBV vaccines prepared from human plasma. Synthetic peptides as alternate vaccines); The delta agent (Serial passage of the delta agent in chimpanzees, Terminal dilution experiments in chimpanzees, Transmission of the delta agent to WHV-carrier woodchucks, Epidemiology of the delta agent); Nucleic acids - detection and analysis (Delta associated RNA (DAR), Detection and analysis of hepadna-DNA sequences, HBV cloning and expression of HBsAg genes in eukaryotic cells); Respiratory syncytial virus (RSV) (RSV proteins, Paget's disease, Comparison of RSV strains by neutralization and RIP assays, Antigen purification, Animal studies, BCH4 cells), Hybridoma studies.