Sorbents for Application in the Treatment of ESRD Patients

摘要

In order to determine the optimum combination of peritoneal dialysis parameters, clinical studies were performed on ESRD patients maintained by CAPD measuring the effects of residual volume, stroke volume, dialysate flow rate, patient activity and dialysate temperature on uremic solute clearance. The average dialysate flow rate is the major determinant of clearance. Patient activity and stroke volume are also important, whereas residual volume, outflow rate, and dialysate temperature did not cause significant changes. A peritoneal dialysis machine for sorbent continuous peritoneal dialysis for overnight use has been designed. This will deliver an inflow rate of 200 ml/min, zero dwell time and an outflow rate of 40 ml/min. The average flow rate will be 33 ml/min. For a wearable sorbent peritoneal artificial kidney, it appears that the device should incorporate an inflow rate of approximately 100 ml/min and an outflow rate of approximately 18 ml/min. This would permit the use of smaller sorbent cartridges and filters while maximizing clearance.