Pilot National Environmental Specimen Bank - Analysis of Human Liver Specimens

摘要

The work was performed under a joint EPA/NBS research program to develop state-of-the-art protocols for the sampling, storage, and analysis of biological and environmental-type matrices as part of a Pilot National Environmental Specimen Bank program. The purpose of this report is to summarize the experience and results obtained for the first sample type, human liver. The sample collection protocol was evaluated with respect to costs and suitability of donor selection criteria. An analytical protocol was implemented for the determination of trace elements in the liver samples using the techniques of atomic absorption spectrometry, isotope dilution mass spectrometry, neutron activation analysis, and voltammetry. Individual sections of this report describe in detail the procedures used and the results obtained for each of these analytical techniques. The analytical results for the determination of 31 trace elements in 36 liver specimens are presented and discussed. Analytical methodology for the measurement of organochlorine compounds is also described.