Task I Preclinical Single and Five Daily Dose, Range-Finding and Lethality Studies in CD2F1 Mice, and Toxicity Studies in Beagle Dogs and CD2F1 Mice Administered Caracemide (NSC 253272)

摘要

The single dose (intravenous) range-finding and lethality studies of NBC 253272 in CD2F(1) mice are reported. Combined sex LD(10), LD(50), and LD(90) values obtained were 278.34, 312.61, and 351.09 mg/kg (835.02, 937.83, and (1053.27 mg/sq m), respectively. Toxic signs included lethargy, irregular breathing, clonic and/or tonic convulsions, hyperactivity, gasping, muscle tremors, prostration and loss of bladder control. Although completely reversible, the single dose lethality study demonstrated a fairly prolonged duration of toxicity, lasting several days post-treatment. Five daily dose range-finding and lethality studies are also reported.