Task I Preclinical Single and Five Daily Dose, Range-Finding and Lethality Studies in CD2F1 Mice, and Toxicity Studies in Beagle Dogs Administered NSC-253272

摘要

The single dose (intravenous) range-finding and lethality study of NSC 253272 in CD2F1 mice are reported. Combined sex LD10, LD50, and LD90 values obtained were 278.34, 312.61, and 351.09 mg/kg (835.02, 937.83, and 1053.27 mg/sq m) respectively. Toxic signs included lethargy, irregular breathing, clonic and/or tonic convulsions, hyperactivity, gasping, muscle tremors, single dose lethality study demonstrated a fairly prolonged duration of toxicity, lasting several days post-treatment. Five daily dose range-finding and lethality studies are also reported.