Maternal Hepatic and Embryonic Effects of 1,2,4- Trichlorobenzene in the Rat

摘要

The possible maternal hepatic and reproductive effects of 1,2,4-trichlorobenzene (TCB) were assessed in rats given 0, 36, 120, 360, and 1200 mg/kg/day of TCB on Days 9-13 of gestation. The animals were sacrificed on Day 14 of pregnancy. Maternal deaths (2/9 rats 6/6 rats) were recorded in the 360 and 1200 mg/kg/day treatment groups and body weights gain was significantly decreased in the 360 mg/kg/day TCB group. Maternal liver weight liver/body weight ratio, and hepatic microsomal protein content were unaffected by TCB treatment.