Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered Via Subcutaneous Silastic (Trade Name) Implants

摘要

Bisphenol A (BPA) was examined in a new reproductive toxicology testing scheme which has been designated 'Fertility Assessment by Continuous Breeding'. Continuous exposure to BPA for 2 weeks via subcutaneous Silastic implants containing 0, 6.25, 12.5, 25, 50 or 100 mg BPA during Task 1 (dose range-finding study) caused no overt toxicity, but did seem to increase the weight of the reproductive tract weight in high dose females.