Diethyl Phthalate: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed

摘要

Diethyl phthalate was evaluated in a new reproductive toxicology testing scheme which has been designated 'Fertility Assessment by Continuous Breeding'. Task 1 (dose-range finding) was performed to aid in the selection of dose levels for Task 2 (continuous breeding). Eight male and female CD-1 mice (8 weeks of age) per dose group were given 0.0, 0.25, 0.50, 1.0, 2.5 and 5.0% DEP in their feed for 14 days. No deaths were recorded during the 14-day treatment period and no signs of toxicity were observed in any of the dose groups.