Detection of Ethylene Dibromide and 2-Ethoxyethanol in the Blood and Semen of Rabbits

摘要

The possibility of monitoring the concentration of toxicants in semen was examined using 16 male Dutch-belted-rabbits given either 1000mg/kg of 2-ethoxyethanol (110805) (EE) or 22mg/kg ethylene dibromide (106934) (EDB) by gavage. Blood concentrations for EE peaked between 1 and 1.5 hours after administration and then rapidly declined. Semen levels of EE closely paralleled those in the blood, but they were consistently higher in the semen. The mean blood concentrations for EDB peaked in 30 minutes and appeared to go through a distribution phase before the terminal dieaway. Levels of EDB in the semen were extremely variable. The blood and semen concentrations of EDB did not show a clear relationship. EDB itself was completely metabolized and not detected in the urine. EDB may have caused organ changes. Due to the unpredictability of the semen concentrations, the authors conclude that blood level concentrations of EDB should not be taken as indicative of what the semen levels are at the same time.