Toxicology and Carcinogenesis Studies of 2-Chloroethanol (Ethylene Chlorohydrin) (CAS NO. 107-07-3) in F344/N Rats and Swiss CD-1 Mice (Dermal Studies)

摘要

Toxicology and carcinogenesis studies of 2-chloroethanol (99% pure) , an industrial chemical and an intermediate in the synthesis of ethylene oxide, were conducted by dermal application of 2-chloroethanol dissolved in 70% ethanol:30% water (v/v) solutions to groups of 50 F344/N rats of each sex at doses of 0, 50, or 100 mg/kg for 103 weeks or to groups of 50 Swiss CD-1 mice of each sex at doses of 0, 7.5, or 15 mg per animal for 104 weeks (0, 253, or 630 mg/kg at week 1; 0, 180, or 411 mg/kg at week 100). The control groups received skin applications of the vehicle; the mouse studies also included untreated control groups of 50 males and 50 females. 2-Chloroethanol solutions were applied to the clipped interscapular area of the animals once daily, 5 days per week for the test period. Rats received a volume of 0.18-0.22 ml of solution; mice received 0.10 ml of solution. In the 13-week studies, mortality was observed in male and female rats receiving 250 mg/kg per day and higher and in male and female mice receiving 20 mg per day and higher. In the 104-week studies, the survival and body weights of dosed rats were unaffected by 2-chloroethanol.