Subchronic Toxicity of Tetrachloroethylene (Perchloroethylene) Administered in the Drinking Water of Rats

摘要

The study provides data on the effects of tetrachloroethylene in drinking solutions. The acute oral LD(50) was determined in male and female Charles River rats and found to be 3835 mg/kg for males and 3005 mg/kg for females. Male and female rats received theoretical daily doses of 14,400 and 1400 mg tetrachloroethylene/kg bw/day for 90 consecutive days. There were no compound related deaths. There were no consistent dose related effects on any of the hematological or urinalysis parameters. There were no gross pathological effects observed. Liver and kidney ratios were elevated at the higher doses. There was no apparent evidence of accumulation. These data suggest that exposure of humans to reported levels of tetrachloroethylene in drinking water does not constitute a serious health hazard.