Genetic Activity Profiles of Chemicals Selected from the Aneuploidy Data Base

摘要

A committee of scientists was established by the U.S. Environmental Protection Agency to appraise the current state of aneuploidy test methodology, to compile and analyze published data on the chemical induction of aneuploidy, and to provide guidance for additional test development and validation. The committee was organized into 9 working groups, representing different eukaryotic organisms ranging from fungi to whole mammaals. The Environmental Mutagen, Carcinogen, and Teratogen Information Program at Oak Ridge National Laboratory identified and provided literature to the working groups. The 9 reports were prepared by the individual working groups. The reports include: (1) descriptions of the available testing approaches and general principles to be followed for protocol development, (2) criteria for evaluating data, and (3) recommendations for future test development and basic research. The evaluated results are presented in tables. For the positive and negative calls, the lowest effective dose tested or the highest ineffective dose tested, respectively, and the range of concentrations tested are provided. An overall summary report was prepared that summarizes the conclusions and recommendations of the 9 working groups and the chemical data base. It is hoped that these reports will provide a framework for further test development and validation of aneuploidy assays.