Computer-Automated Prediction of the Mutagenicity of Benzidine, 4,4(double prime)-Diaminoterphenyl, 4-Dimethylaminoazo-benzene and 4-Cyanodimethylaniline: Comparison with the Results of the Second UKEMS Collaborative Study

摘要

There was agreement between the experimental results, obtained in the course of the Second UKEMS Collaborative Study, for the mutagenicity in Salmonella typhimurium of benzidine, 4,4'-diaminoterphenyl, 4-dimethylaminoazobenzene and 4-cyanodimethylanidine and the mutagenicity predicted by CASE (Computer Automated Structure Evaluation), a recently developed artificial intelligence system.