Genetic and Biological Markers in Drug Abuse and Alcoholism

摘要

The monograph is based upon papers and discussion from the technical review on genetic and biological markers for drug abuse and alcoholism which was held on November 28 and 29, 1984 at Rockville, Maryland. Contents include: Genetic and biological markers in drug abuse and alcoholism: a summary; Polymorphic gene marker studies; Individual differences in opiate-induced alterations at the cytogenetic, DNA repair, and immunologic levels: opportunity for genetic assessment; Pharmacogenetic approaches to the prediction of drug response; Studies on an animal model of alcoholism; Development of DNA probes to investigate genetic variation of alcohol metabolizing enzymes; Genetics as a tool for identifying biological markers of drug abuse; Genetic markers of drug abuse in mouse models; Inheritance of risk to develop alcoholism; Genetic and biological markers in alcoholism and drug abuse; and recommendations for future research on genetic and biological markers in drug abuse and alcoholism.