Development of Live, Attenuated Cold-Adapted (CA) Influenza Vaccines. Annual Report October 25, 1985-October 24, 1986

摘要

The report covers the following: Update of antigenic composition and development of wild-type influenza virus types A and B; Preparation of suitable 6/2 cold-adapted reassortants; Analysis of single gene reassortants; Characterization of isolates from vaccine trials in Houston; Polyvalent studies - Polyvalent live preparation in the ferret model; Sequence comparison of wild type and cold-adapted B/AA/1/66 viruses - NS, M & NP genes; Terminal deoxynucleotidyl transferase eliminates sequence ambiguities in chain termination sequencing of RNA.