In-Depth Survey Report: Control Technology Assessment of Enzyme Fermentation Processes at Novo Biochemical Industries, Inc., Franklinton, North Carolina

摘要

An in-depth survey was made of the Novo Biochemical Industries, Inc. (NBI) (SIC-2869), facility located in Franklinton, North Carolina, to evaluate the controls and containment capabilities employed in their alpha-amylase enzyme manufacturing process. The process at the facility used a strain of Bacillus licheniformis to produce alpha-amylase. Possible hazardous exposures at the facility included hazardous microorganisms, toxic processing chemicals, and biologically active products or intermediates. NBI uses a relatively advanced computer controlled and monitored process technology which limits direct employee involvement and potential hazard exposure. Potential exposures in the laboratory process, fermentation process, and recovery process steps are considered and NBI's work practices, environmental health monitoring program, and personal protection requirements are discussed. The author concludes that the results of the viable air sample analysis indicate an effective system of control measures.