Mutagenesis of the Metabolite of Nonionic Detergents in Water

摘要

Biochemical decomposition of nonionic detergents under aerobic and anaerobic conditions yield a metabolite, 4-nonylphenol. Studies were conducted using Ames Standard and preincubation test procedures to determine the mutagenic activity of nonylphenol. Tester strains used were TA97, TA98, TA100, TA102 and TA104. Both spot test and preincubation tests were done with and without S9 activation. The results obtained show that nonylphenol is not a mutagenic compound under the test conditions. Dose response studies showed that it was toxic at higher concentration (100 ug/plate). Nonylphenol should be further tested for its toxicity to Salmonella strains. DDT and DDE were also not mutagenic as determined by the Ames test.