Methoxy Acetic Acid: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water

摘要

Methoxy acetic acid was evaluated in a new reproductive toxicology testing scheme which has been designated 'Fertility Assessment by Continuous Breeding'. In the present study, Task 1 (dose-range finding) was not performed because there was sufficient information in the literature to allow selection of dose levels for Task 2 (continuous breeding). For the continuous breeding phase (Task 2) doses of 0.0, 0.1, 0.2, 0.4% MAA in the drinking water were selected by the Project Officer and administered to the test animals. Analysis of the Task 2 drinking water formulations at six week intervals indicated they ranged from 100 to 103% of the desired MAA concentration. Assuming that a male or female mouse weighing 40.0 g consumed an average of 7.0 ml/day drinking water, levels of MAA chosen for Task 2 represented daily intakes of 0.0, 175.0, 350.0 and 700.0 mg/kg/day.