Testing of Respiratory, Enteric and Bacterial Vaccines and Epidemiology of Infectious Diseases in Children. Annual Report November 1985-September 1986

摘要

The present report covers the period November 15, 1985 to September 30, 1986. In that period of time the Vaccine Clinic was maintained at a size of 230 children. Respiratory surveillance demonstrated a large RS epidemic and influenza B. Further trials of simultaneously administered cold adapted vaccines (H1N1 (A/Texas CR 98) and H3N2 (A/Bethesda/CR-90)) in doubly-seronegative children showed the majority of virus shed to be H1N1 and the HAI response to be directed primarily against this component. Rotavirus vaccine evaluation continued. Shedding of serotype 1 vaccine is strongly influenced by preexisting antibody suggesting that such naturally acquired antibody is more likely to be directed against this more common serotype. A conjugated haemophilus vaccine DPO-1 was evaluated in infants with a response to 3 doses before 6 months in 14/16 children. Results with a trial of acellular pertussis vaccine were prepared and accepted for publication.