New Vaccine Development Establishing Priorities. Volume 2. Diseases of Importance in Developing Countries

摘要

The report presents a comprehensive method designed to help government decision makers set priorities for accelerated development of vaccines against important diseases in the developing world. The method can be used to assess new vaccine candidates or to reassess current contenders as additional information becomes available. The primary utilization of many of these vaccines would be for reducing morbidity and mortality in developing countries. Other uses would be for U.S. travelers to such countries and for response to the importation of these diseases (e.g., dengue fever) and their transmission in the United States. The decision-making approach suggested uses similar kinds of information about the occurrence and importance of events that theoretically could be used in other methods of decision making. Because information is incomplete and because the method entails, in some instances, predicting the future, gaps must be filled by estimates or judgments by experts.