Toxicology and Carcinogenesis Studies of Chlorinated Trisodium Phosphate (CAS No. 56082-99-4) in B6C3F1 Mice (Gavage Studies)

摘要

Toxicology and carcinogenesis studies of chlorinated trisodium phosphate were conducted by administering 0, 500, or 1,000 mg/kg (dose volume: 10 ml/kg) of the chemical in water by gavage, 5 days per week for 103 weeks, to groups of 50 B6C3F sub 1 mice of each sex. Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenicity for either male or female B6C3F sub 1 mice given chlorinated trisodium phosphate by gavage in water for 103 weeks at doses of 500 or 1,000 mg. Survival of dosed female mice was 78% and 72% after 80 weeks and 32% and 42% at the termination of the study. The studies in male and female F344/N rats were considered to be inadequate studies of carcinogenicity because the experiments were terminated at 35 weeks due to poor survival.