Hazard Assessment Using an Integrated Physiologically-Based Dosimetry Modeling Approach: Ozone

摘要

A physiologically-based dosimetry modeling approach can provide a framework for integrating various components of hazard assessments to obtain interspecies dose-response curves as part of the risk assessment process. The methodology presented for developing dose-response curves is illustrated within the context of the inhalation toxicology of a ubiquitous air pollutant, ozone. Major components of the approach are discussed, including a data-based management system, the Critical Toxicity Reference System, and a physiological based dosimetry model for ozone absorption in the lower respiratory tract of mammals. Features and characteristics of the two components are discussed. When the ozone dosimetry modeling approach is sufficiently developed, it can provide improved estimates for dose-response relationships in experimental animals, leading to improved estimates of human health risks.