EPA's (Environmental Protection Agency's) Draft Drinking Water Criteria Document for Monochlorobenzene. Technical Comments of the Halogenated Organics Subcommittee

摘要

The Halogenated Organics Subcommittee evaluated the animal evidence for carcinogencity of chlorobenzene to be 'inadequate' under EPA's new guidelines based on the lack of a statistically significant increase in the incidence of tumors in female mice, male mice and female rats, and on the basis of the perception of a diminished biologic significance of reported malignant neoplastic nodules of the liver in the highest dose-treated male rats. The evidence would place chlorobenzene into the overall weight-of-the-evidence category D (not classified).