Carcinogenicity of Trichloroethylene and Its Metabolites, Trichloroacetic Acid and Dichloroacetic Acid, in Mouse Liver

摘要

Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when given by daily gavage in corn oil. The metabolism of TCE results, in part, in the formation of trichloroacetic acid (TCA) as a major metabolite and dichloroacetic acid (DCA) as a minor metabolite. These chlorinated acetic acids have not been shown to be genotoxic; although, they have been shown to induce peroxisome proliferation. Therefore, the authors determined the ability of TCE, TCA, or DCA to act as tumor promoters in mouse liver. Therefore our results demonstrate that DCA and TCA are hepatocarcinogens in B6C3F1 mice although there has been no previous evidence of their geonotoxicity. (Copyright (c) 1987 by Academic Press, Inc.)