Toxicology and Carcinogenesis Studies of Methyl Carbamate (CAS No. 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

摘要

Two-year studies of methyl carbamate were conducted by administering doses of 0, 100, or 200 mg/kg methyl carbamate in distilled water by gavage, 5 days per week for 103 weeks, to groups of 50 F344/N rats of each sex. Groups of 50 B6C3F1 mice of each sex were administered doses of 0, 500, or 1,000 mg/kg methyl carbamate on the same schedule. Additional groups of 30 rats of each sex were administered 0 or 400 mg/kg methyl carbamate, and additional groups of 30 mice of each sex were administered 0 or 1,000 mg/kg methyl carbamate in distilled water by gavage, 5 days per week. Ten animals from each group were killed at 6, 12, or 18 months so that the progression of lesions could be followed. Under the conditions of these studies, there was clear evidence of carcinogenic activity for male and female F344/N rats. There was no evidence of carcinogenic activity for male and female B6C3F1 mice given methylcarbamate at doses of 500 or 1,000 mg/kg.