Update to the Health Assessment Document and Addendum for Dichloromethane (Methylene Chloride): Pharmacokinetics, Mechanism of Action, and Epidemiology. External Review Draft

摘要

The document represents EPA's analysis of the weight of evidence regarding the carcinogenic potential of dichloromethane (DCM, methylene chloride) for humans. It includes revised cancer risk estimates that take into account the newest information on pharmacokinetics, mechanism of action, and epidemiology, and it discusses, in some detail, methods for incorporating pharmacokinetic information into the cancer risk assessment. The document draws on the body of work developed by the Hazard/Risk Assessment Committee (HRAC) of the Integrated Chlorinated Solvents Project, an interagency workgroup. For the present, EPA scientists have used methods that result in an approximate ninefold reduction from previous unit estimates which were based on applied dose.