Screening of Priority Chemicals for Reproductive Hazards. Monoethanolamine (Cas. No. 141-43-5); Diethanolamine (Cas. No. 111-42-2); Triethanolamine (Cas. No. 102-71-6)

摘要

Monoethanolamine (141435), diethanolamine (111422), and triethanolamine (102716) were screened for their ability to cause adverse reproductive effects using a postnatal mouse screening test. Phase one and two of the tests involved the determination of the median lethal dose for these chemicals and the third phase involved the reproductive effects study. Monoethanolamine, administered at 850 mg/kg/day, was toxic to pregnant animals causing a 16% mortality. Monoethanolamine reduced the number of viable litters but did not affect litter size, the percent survival of the pups, the birth weight of the pups or the weight gained by the pups. Diethanolamine, administered at 1125 mg/kg/day, caused no change in maternal mortality, number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups. Triethanolamine, administered at 1125 mg/kg/day, did not affect maternal mortality, the number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups.