Twenty-One Day Exposure to Mixed Air Pollutants: Effects on Lung Airways and Macrophages

摘要

The investigators exposed rats to a 7 component mixture (consisting of ozone, nitrogen dioxide, sulfur dioxide, ammonium sulfate, ferric sulfate, manganese sulfate, and ferric oxide). The exposures lasted for 4 hours per day for either 7 or 21 days. They observed significant effects on pulmonary macrophage function, with more pronounced effects seen after 21 days of exposure. These effects persisted up to 96 hours post-exposure. No statistically significant effects on nasal or bronchoalveolar epithelial permeability were detected.