Alpha(2)-Adrenergic Mode of Action of Chlordimeform on Rat Visual Function

摘要

The hypothesis that chlordimeform increased the amplitude of components N;P1 and P1N3 in rat pattern-reversal visual evoked potentials through actions on alpha2 adrenergic receptors was tested. Yohimbine alone had no effect on pattern-reversal evoked potential amplitude. Clonidine treatment produced a dosage related increase in amplitude of both components similar to that produced by chloroimeform. Yohimbine pretreatment attenuated the effects of subsequent treatment with either clonidine or chlordimeform. The results support the hypothesis that chlordimeform alters rat pattern-reversal evoked potentials through actions as a central nervous system alpha2 adrenergic agonist. (Copyright (c) Academic Press, Inc.)