Detection of CCl4-Induced Oxidation of Hepatic Tissue In vivo by Oxygen-18 Tracing

摘要

Oxygen can become a damaging influence in tissues and cells exposed to environmental pollutants. The paper describes the first application of a new technique for tracing oxygen in tissues exposed to pollutants. Carbon tetrachloride (CCl4) was found to cause oxidation of liver tissue in rats which was measurable using oxygen-18 labeling procedures. Rats which breathed oxygen-18 while being exposed to CCl4 were found to have oxidized lipids, macromolecules and water-soluble substances in their livers. The techniques outlined in the paper should be useful for elucidating mechanisms of injury and increased aging of tissues exposed to pollutants. (Copyright (c) 1988 Academic Press, Inc.)