Plasma Binding of 1-Butanol, Phenol, Nitrobenzene and Pentachlorophenol in the Rainbow Trout and Rat: A Comparative Study

摘要

The in vitro binding of 1-butanol, phenol, nitrobenzene, and pentachlorophenol in trout plasma and rat plasma was determined. Binding to rainbow trout plasma proteins agreed within 9% of that observed in rat plasma. Percentage bound to rainbow trout (2-99%) or rat (10-99%) plasma proteins increased as the log octanol/water partition coefficient of the chemicals increased within the Log P 1-3 range, and was suggestive of hydrophobic interactions in binding.