Evaluation of the Potential Carcinogenicity of Chloromethyl Methyl Ether (Technical Grade) (107-30-2)

摘要

Technical grade chloromethyl methyl ether is contaminated with between 1 and 8 percent bis(chloromethyl)ether, which is a known human carcinogen. The human evidence for this compound and the hazard ranking are based on the evidence for bis(chloromethyl)ether. Technical grade chloromethyl methyl ether (which is always contaminated with bis(chloromethyl)ether) is therefore considered to be a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). The evidence from human studies, including those for bis(chloromethyl)ether, is 'Sufficient'. The evidence from animal studies on chloromethyl methyl ether alone is 'Inadequate'. Combining the weight-of-evidence group and the potency group 1 for the contaminant bis(chloromethyl)ether, chlormethyl methyl ether is assigned a 'HIGH' hazard ranking for the purposes of RQ adjustment.