Evaluation of the Potential Carcinogenicity of Bis(Chloromethyl)Ether (542-88-1)

摘要

Bis(chloromethyl)ether is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Sufficient'. The potency factor (F) for bis(chloromethyl)ether is estimated to be 10,377/(mg/kg/day), placing it in potency group 1 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, bis(chloromethyl)ether is assigned a 'HIGH' hazard ranking for the purposes of RQ adjustment.