Pilot Study on International Information Exchange on Dioxins and Related Compounds. Scientific Basis for the Development of the International Toxicity Equivalency Factor (I-TEF) Method of Risk Assessment for Complex Mixtures of Dioxins and Related Compounds

摘要

The Pilot Study on International Information Exchange on Dioxins and Related Compounds was initiated to apply the cooperative efforts of several nations to address issues assoc. with PCDDs, PCDFs, and related compounds. The three-year study was conducted under the aegis of the CCMS of NATO. The report presents a detailed discussion of the scientific basis for the development of toxicity equivalency factors and provides the toxicity data and methodology used to determine the I-TEFs. Section 2 discusses background information on PCDDs and PCDFs. Section 3 discusses the need for I-TEFs. Section 4 presents the mechanisms of toxicity of these compounds. Section 5 provides a discussion of the development of TEFs from experimental toxicity data.