Effects of Ozone on Cellular Synthesis and Viral Replication In vitro

摘要

The project used a system developed for exposing isolated cells and tissues to ozone to address three major objectives: to determine the effect of ozone on the replication of several human and animal viruses; to investigate the effects of ozone on rates of macromolecular synthesis in several cell lines; and to measure the effects of ozone on the ability of tracheal tissue to produce interferon. The major result was that cells infected with viruses either during or after ozone exposure were capable of supporting normal viral replication. A separate result showed that cellular damage generally increased with increased ozone exposures and that longer exposure times appeared to cause cellular changes that were not apparent after shorter exposure times. Additionally, ozone exposures had no effect on the ability of isolated tracheas to produce interferon.