Estimating Toxicity of Industrial Chemicals to Aquatic Organisms Using Structure Activity Relationships. Volume 1

摘要

The report presents 49 SARs (Structure Activity Relationships) which are currently used by the EPA Environmental Effects Branch to estimate the toxicity of industrial organics to aquatic organisms. These SARs can be applied to three broad categories of organic chemicals: (1) neutral organics which are non-reactive and non-ionizable, (2) neutral organics which are reactive and show excess toxicity in addition to narcosis, and (3) surface active organic compounds such as surfactants, and polycationic polymers. There are about 40 classes and sub-classes of organic compounds covered by these SARs. The scope of these SARs include acute toxicity to vertebrates and invertebrates (freshwater and saltwater species), chronic toxicity to freshwater vertebrates and invertebrates, and toxicity to freshwater algae.