Mouse Teratogen Dinocap Has Lower A/D Ratios and Is Not Teratogenic in the Rat and Hamster (Journal Version)

摘要

The fungicide dinocap is currently used in the control of powdery mildew. The authors have reported that dinocap is teratogenic in the CD-1 mouse, causing cleft palate, otolith defects, and fetal weight deficits well below maternotoxic dose levels. In the study the maternal and fetal toxicity of dinocap was determined in the Sprague-Dawley rat and Syrian golden hamster, and Adult-to-Developmental (A/D) toxicity ratios were calculated and compared to the previously established A/D ratio of dinocap in the mouse. The A/D ratios for dinocap in the rat and hamster are similar, and are approximately one. These previous studies have demonstrated that dinocap is teratogenic in the mouse, with an A/D ratio in the range of 8-16 in the species. The basis for the species-specific teratogenicity and inconsistent A/D ratio of dinocap is unknown.