Applicability of U.S. EPA (Environmental Protection Agency) Risk Assessment Guidelines for Chemical Mixtures

摘要

The U.S. EPA published Guidelines for the health Risk Assessment of Chemical Mixtures in September, 1986. To facilitate the application of Guidelines procedures the Agency has developed a data base on known toxicological interactions (synergism, etc.). This unique resource allos incorporation of interaction data on a case-by-case basis into mixture risk assessments. Additional technical support information is being compiled, which will provide the scientific basis for the Guidelines procedures. In the present paper, the Guidelines still be summarized and illustrated using an example assessment of contaminated ground water.