Toxicology and Carcinogenesis Studies of 4-Vinyl-1-Cyclohexene Diepoxide (Cas No. 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

摘要

Toxicology and carcinogenesis studies were conducted by administering 4-vinyl-1-cyclohexene diepoxide in acetone to groups of 60 rats of each sex at doses of 0, 15, or 30 mg/animal by dermal application to the clipped dorsal interscapular region, 5 days per week for 15 months or 105 weeks. 4-Vinyl-1-cyclohexene diepoxide in acetone was administered to groups of 60 mice of each sex at doses of 0, 2.5, 5, or 10 mg/animal in the same manner. Under the conditions of these 2-year dermal studies, there was clear evidence of carcinogenic activity of 4-vinyl-1-cyclohexene diepoxide for male and female F344/N rats, as shown by squamous cell and basal cell neoplasms of the skin. There was clear evidence of carcinogenic activity of 4-vinyl-1-cyclohexene diepoxide for male and female B6C3F1 mice, as shown by squamous cell carcinomas of the skin and ovarian neoplasms in females; increased incidences of lung neoplasms in females may also have been related to chemical application.